Solution synthesis of a dimeric pentapeptide: Diketopiperazine cyclisation of Glu-Asp dipeptide esters and Asp-racemisation during segment condensation

DOI: 10.1016/S0040-4020(01)85085-7

Source and publish data:

Tetrahedron p. 2277 - 2288 (1994)

Update date:2022-08-05

Topics: Characterization Protection of Functional Groups Deprotection and Purification

Authors:

Fischer Fischer

Solbakken

Undheim Undheim

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Article abstract of DOI:10.1016/S0040-4020(01)85085-7

A haemoregulatory peptide analogue derived from the cystine-dimerised pentapeptide Glp-Glu-Asp-Cys-Lys-OH, in which the cystine residue has been replaced by an isosteric L,L-2,7-diaminosuberic acid moiety, was prepared by segment condensation in solution.

Full text of DOI:10.1016/S0040-4020(01)85085-7

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Product name:L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) 1-(2-propenyl) ester

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