1279712-25-2Relevant academic research and scientific papers
α-d-Mannose derivatives as models designed for selective inhibition of Golgi α-mannosidase II
Poláková, Monika,?esták, Sergej,Lattová, Erika,Petru?, Ladislav,Mucha, Ján,Tvaro?ka, Igor,Kóňa, Juraj
, p. 944 - 952 (2011)
Human Golgi α-mannosidase II (hGM) is a pharmaceutical target for the design of inhibitors with anti-tumor activity. Nanomolar inhibitors of hGM exhibit unwanted co-inhibition of the human lysosomal α-mannosidase (hLM). Hence, improving specificity of the
