1279815-59-6

Basic information

• Product Name: tert-butyl 3-oxo-4-(pyridin-2-yl)piperazine-1-carboxylate
• Synonyms: tert-butyl 3-oxo-4-(pyridin-2-yl)piperazine-1-carboxylate
• CAS NO: 1279815-59-6
• Molecular Weight: 277.323
• Mol File: 1279815-59-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-oxo-4-(pyridin-2-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-oxo-4-(pyridin-2-yl)piperazine-1-carboxylate(1279815-59-6)
• EPA Substance Registry System: tert-butyl 3-oxo-4-(pyridin-2-yl)piperazine-1-carboxylate(1279815-59-6)

Safety Data

• Hazardous Substances Data: 1279815-59-6(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 76003-29-7 4-(t-butyloxycarbonyl)piperazin-2-one 
• 5029-67-4 2-iodopyridine 

Downstream Products

• 345310-98-7 1-(2-pyridyl)piperazin-2-one 

Relevant articles and documents

Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl pepdidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)- butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clinical development.