1279819-87-2

Upstream product

• 186581-53-3 diazomethane 
• 124-38-9 carbon dioxide 
• 1237534-74-5 tert-Butyl {(phenylsulphonyl)[3-(trifluoromethyl)phenyl]methyl}-carbamate 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 4248-19-5 tert-butyl carbazate 
• 242475-26-9 2-amino-2-(3-(trifluoromethyl)phenyl)acetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1245623-25-9 tert-butyl-(2-hydroxy-1-(3-(trifluoromethyl)phenyl)ethyl)(methyl)carbamate 

Relevant academic research and scientific papers

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.

One-pot synthesis of α-amino acids from CO2 using a bismetal reagent with Si-B bond

In the presence of 1.1 equiv of PhMe2Si-Bpin, 5 equiv of CsF, and 20 mol % of TsOH·H2O, precursors of N-Boc-imines can be converted into the corresponding α-aryl or α-alkenyl glycine derivatives under gaseous CO2 in moderate-to-high yields with a single operation. α-Isobutenyl glycine thus obtained can be further derivatized into various types of α-amino acids including N-Boc-leucine, serine, and glycine derivatives in short steps.