127984-23-0Relevant articles and documents
DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA)
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Paragraph 0369; 0370, (2013/06/06)
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
A practical stereoselective synthesis of both enantiomers of Threo- and Erythro-β-hydroxy norvaline from (S)-serine derivatives
Andrés, José M.,Elena, Noemí De,Pedrosa, Rafael
, p. 1523 - 1531 (2007/10/03)
The four enantiopure diastereoisomers of β-hydroxy norvaline have been prepared from L-serine in moderate chemical yield. The method is based on the diastereoselective addition of different organometallics to easily accessible serinal derivatives. (C) 2000 Elsevier Science Ltd.
Chiral 4,5-Disubstituted Oxazolidin-2-ones: Stereoselective Synthesis of β-Hydroxy-α-amino Acids
Giovanni, Maria Cristina Di,Misiti, Domenico,Zappia, Giovanni,Monache, Giuliano Delle
, p. 475 - 482 (2007/10/03)
The stereocontrolled synthesis of β-hydroxy-α-amino acids from O-benzyl D- and L-serine, by the use of 4,5-disubstituted oxazolidin-2-ones as chiral intermediates, is presented as a suitable alternative to the known procedures.The reported synthesis of both enantiomers of threo-3-hydroxyglutamic acid and (2S,3R)-3-hydroxyproline together with a flexible and stereodivergent preparation of threonine analogues is discussed as an example of the versatility of the present approach.