127984-23-0Relevant articles and documents
DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA)
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Paragraph 0369; 0370, (2013/06/06)
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
A practical stereoselective synthesis of both enantiomers of Threo- and Erythro-β-hydroxy norvaline from (S)-serine derivatives
Andrés, José M.,Elena, Noemí De,Pedrosa, Rafael
, p. 1523 - 1531 (2007/10/03)
The four enantiopure diastereoisomers of β-hydroxy norvaline have been prepared from L-serine in moderate chemical yield. The method is based on the diastereoselective addition of different organometallics to easily accessible serinal derivatives. (C) 2000 Elsevier Science Ltd.
An enantioselective, stereodivergent synthesis of threonine analogs
Delle Monache, Giuliano,Di Giovanni, Maria Cristina,Misiti, Domenico,Zappia, Giovanni
, p. 231 - 243 (2007/10/03)
An enantioselective and stereodivergent methedology for the synthesis of the four isomers of P-hydroxy norvaline is presented starting from the common oxazolidin-2-one intermediate 1, via an iterative formation of the oxazolidin-2-one ring to achieve the stereochemical control of the stereogenic centers. The flexibility of the present approach, for the synthesis of several threonine analogs, lies in the ready displacement of the sulfonate group in 2 with the Grignard reagents in the presence of CuI.