127984-93-4 Usage
General Description
1-amino-5-bromouracil is a chemical compound with the molecular formula C4H4BrN3O2. It is a derivative of uracil, a naturally occurring nucleobase found in RNA and DNA. 1-amino-5-bromouracil is commonly used as a mutagen in genetic research and studies due to its ability to alter the genetic code by causing point mutations. It is known to form base pairs with adenine, cytosine, and guanine, and has been used to study the mechanisms of DNA replication, repair, and recombination. Additionally, this chemical can also exhibit antimicrobial and antifungal properties, making it useful in pharmaceutical and agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 127984-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,9,8 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 127984-93:
(8*1)+(7*2)+(6*7)+(5*9)+(4*8)+(3*4)+(2*9)+(1*3)=174
174 % 10 = 4
So 127984-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H4BrN3O2/c5-2-1-8(6)4(10)7-3(2)9/h1H,6H2,(H,7,9,10)
127984-93-4Relevant articles and documents
Anxiolytic drugs
-
, (2008/06/13)
The present invention relates to an anxiolytic drug comprising as an active ingredient a 1-amino-5-halogenouracil represented by formula [I]: STR1 wherein X represents a halogen atom, or pharmaceutically acceptable salt thereof.
Novel uracil derivatives: Newly synthesized centrally acting agents
Imaizumi,Kano,Sakata
, p. 1808 - 1813 (2007/10/02)
A series of 1-amino-5-substituted uracils and their 4-thio or 2,4-dithio substituted analogues were synthesized and assayed for anti-conflict activity in rats and anesthetic activity in mice. 1-Amino-5-halogenouracils 3b-e, 1-amino-4-thiouracil (9a), and 1-amino-5-halogeno-4-thiouracils 9c, d showed both anti-conflict and anesthetic activities. The most active compound was 1-amino-5-chloro-4-thiouracil (9d) which showed anxiolytic activity at 2 mg/kg of oral administration (p.o.) on a modified Geller-Seifter conflict schedule. Its minimum effective dose (MED) was lower than that of diazepam. The 50 percent effective dose (ED50) for anesthetic activity in mice of the compound (9d) was 32.9 mg/kg, p.o.