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127984-93-4

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127984-93-4 Usage

General Description

1-amino-5-bromouracil is a chemical compound with the molecular formula C4H4BrN3O2. It is a derivative of uracil, a naturally occurring nucleobase found in RNA and DNA. 1-amino-5-bromouracil is commonly used as a mutagen in genetic research and studies due to its ability to alter the genetic code by causing point mutations. It is known to form base pairs with adenine, cytosine, and guanine, and has been used to study the mechanisms of DNA replication, repair, and recombination. Additionally, this chemical can also exhibit antimicrobial and antifungal properties, making it useful in pharmaceutical and agricultural applications.

Check Digit Verification of cas no

The CAS Registry Mumber 127984-93-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,9,8 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 127984-93:
(8*1)+(7*2)+(6*7)+(5*9)+(4*8)+(3*4)+(2*9)+(1*3)=174
174 % 10 = 4
So 127984-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H4BrN3O2/c5-2-1-8(6)4(10)7-3(2)9/h1H,6H2,(H,7,9,10)

127984-93-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-amino-5-bromopyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 1-Amino-5-bromouracil

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127984-93-4 SDS

127984-93-4Related news

Effect of 1-amino-5-bromouracil (cas 127984-93-4) on brain monoamine metabolism in rats08/22/2019

The effect of 1-amino-5-bromouracil (ABU), a novel central-acting agent, on monoaminergic neurotransmitter levels of rat brain was investigated. Under the nonstressed condition, ABU (20 and 30 mg/kg intraperitoneally [IP]) did not affect monoamine metabolism, whereas diazepam (5 mg/kg IP) increa...detailed

Effects of 1-amino-5-bromouracil (cas 127984-93-4) on the benzodiazepine-GABAA receptor complex08/21/2019

We investigated the effects of 1-amino-5-bromouracil on the benzodiazepine-γ-aminobutyric acid (GABA)A receptor complex to elucidate its central action. 1-Amino-5-bromouracil neither displaced nor enhanced [3H]muscimol, [35S] t-butylbi-cyclophosphorothionate (TBPS), or [3H]dehydroepiandrosteron...detailed

127984-93-4Relevant articles and documents

Anxiolytic drugs

-

, (2008/06/13)

The present invention relates to an anxiolytic drug comprising as an active ingredient a 1-amino-5-halogenouracil represented by formula [I]: STR1 wherein X represents a halogen atom, or pharmaceutically acceptable salt thereof.

Novel uracil derivatives: Newly synthesized centrally acting agents

Imaizumi,Kano,Sakata

, p. 1808 - 1813 (2007/10/02)

A series of 1-amino-5-substituted uracils and their 4-thio or 2,4-dithio substituted analogues were synthesized and assayed for anti-conflict activity in rats and anesthetic activity in mice. 1-Amino-5-halogenouracils 3b-e, 1-amino-4-thiouracil (9a), and 1-amino-5-halogeno-4-thiouracils 9c, d showed both anti-conflict and anesthetic activities. The most active compound was 1-amino-5-chloro-4-thiouracil (9d) which showed anxiolytic activity at 2 mg/kg of oral administration (p.o.) on a modified Geller-Seifter conflict schedule. Its minimum effective dose (MED) was lower than that of diazepam. The 50 percent effective dose (ED50) for anesthetic activity in mice of the compound (9d) was 32.9 mg/kg, p.o.

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