142590-26-9

Basic information

• Product Name: 1-benzylideneamino-5-bromouracil
• Synonyms: 1-benzylideneamino-5-bromouracil
• CAS NO: 142590-26-9
• Molecular Weight: 294.107
• Mol File: 142590-26-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzylideneamino-5-bromouracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylideneamino-5-bromouracil(142590-26-9)
• EPA Substance Registry System: 1-benzylideneamino-5-bromouracil(142590-26-9)

Safety Data

• Hazardous Substances Data: 142590-26-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 127984-93-4 1-Amino-5-bromouracil 

Downstream Products

• 142590-03-2 5-Bromo-3-methyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 
• 142590-07-6 5-Bromo-3-(4-chloro-benzyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 
• 142590-09-8 5-Bromo-3-(4-bromo-benzyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 
• 142590-13-4 5-Bromo-3-(4-methyl-benzyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Novel uracil derivatives: Newly synthesized centrally acting agents

A series of 1-amino-5-substituted uracils and their 4-thio or 2,4-dithio substituted analogues were synthesized and assayed for anti-conflict activity in rats and anesthetic activity in mice. 1-Amino-5-halogenouracils 3b-e, 1-amino-4-thiouracil (9a), and 1-amino-5-halogeno-4-thiouracils 9c, d showed both anti-conflict and anesthetic activities. The most active compound was 1-amino-5-chloro-4-thiouracil (9d) which showed anxiolytic activity at 2 mg/kg of oral administration (p.o.) on a modified Geller-Seifter conflict schedule. Its minimum effective dose (MED) was lower than that of diazepam. The 50 percent effective dose (ED50) for anesthetic activity in mice of the compound (9d) was 32.9 mg/kg, p.o.