127997-05-1

Basic information

• Product Name: tert-butyl (4R)-4-{(R)-hydroxy[(2R)-5-oxo-2,5-dihydrofuran-2-yl]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
• CAS NO: 127997-05-1
• Molecular Formula: C₁₅H₂₃NO₆
• Molecular Weight: 313.3462
• Mol File: 127997-05-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 476.7°C at 760 mmHg
• Flash Point: 242.1°C
• Density: 1.228g/cm³
• Vapor Pressure: 4.35E-11mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: tert-butyl (4R)-4-{(R)-hydroxy[(2R)-5-oxo-2,5-dihydrofuran-2-yl]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4R)-4-{(R)-hydroxy[(2R)-5-oxo-2,5-dihydrofuran-2-yl]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate(127997-05-1)
• EPA Substance Registry System: tert-butyl (4R)-4-{(R)-hydroxy[(2R)-5-oxo-2,5-dihydrofuran-2-yl]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate(127997-05-1)

Safety Data

• Hazardous Substances Data: 127997-05-1(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4R)-4-{(R)-hydroxy[(2R)-5-oxo-2,5-dihydrofuran-2-yl]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate is a synthetic chemical compound with a complex structure that combines a tert-butyl group with a oxazolidine ring and a dihydrofuran moiety. The molecule contains a chiral center, indicated by the (4R) and (R) prefixes, which confer a specific three-dimensional arrangement to the compound. The presence of a hydroxyl group suggests potential interactions with other molecules through hydrogen bonding, while the tert-butyl and dimethyl groups contribute to the overall sterics and stability of the compound. Overall, tert-butyl (4R)-4-{(R)-hydroxy[(2R)-5-oxo-2,5-dihydrofuran-2-yl]methyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate likely possesses unique chemical properties that could be explored for various applications in organic synthesis, drug discovery, or material science.

Upstream product

• 61550-02-5 (furan-2-yloxy)-trimethylsilane 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 136489-92-4 (S)-tert-Butoxycarbonylamino-((2R,3R,4R,5R,6S)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl)-acetic acid methyl ester 
• 135086-50-9 (R)-2,2-Dimethyl-4-[(R)-((2R,3R,4R)-5-oxo-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl)-trimethylsilanyloxy-methyl]-oxazolidine-3-carboxylic acid tert-butyl ester 
• 135086-52-1 (R)-2,2-Dimethyl-4-((2R,3S,4S,5S,6R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl)-oxazolidine-3-carboxylic acid tert-butyl ester 
• 135086-55-4 1,2,3,4-tetra-O-acetyl-6-deoxy-6-tert-butoxycarbonylamino-α-D-glycero-D-talo-heptopyranuronic acid methyl ester 

Relevant articles and documents

Highly Stereocontrolled Total Synthesis of 6-Deoxy-6-aminoheptopyranuronic Acid Derivatives

An extremely selective synthesis of two novel α-aminouronic acids, the enantio-pair D-10 and L-10, through the butenolide intermediates D-2 and L-2 is described.

THE FOUR-CARBON ELONGATION OF THREE-CARBON CHIRAL SYNTHONS USING 2-(TRIMETHYLSILOXY)FURAN: HIGHLY STEREOCONTROLLED ENTRY TO ENANTIOMERICALLY PURE SEVEN-CARBON α,β-UNSATURATED 2,3-DIDEOXYALDONOLACTONES

The BF3-promoted addition of 2-(trimethylsiloxy)furan to three carbon synthons derived from D- and L-glyceraldehyde, D- and L-serinal, and imines thereof furnishes C7 α,β-unsaturated 2,3-dideoxy-aldonolactone derivatives in high yield, with very high level of diastereoselection.In all the cases, compounds having 4,5-threo:5,6-erythro relative stereodisposition preferentially emerge from the reactions, accompanied by only marginal amounts of 4,5-erythro:5,6-threo epimers.An empirical rule for the rapid assignment of the configuration at C-4 (γ-carbon) of γ-substituted unsaturated and saturated β-butyrolactones is given, based upon the sign of the optical rotation values.