135086-52-1

Basic information

• Product Name: tert-butyl 2,2-dimethyl-4-[(2S,3S,4S,5S,6R)-3,4,5,6-tetraacetoxytetrahydropyran-2-yl]oxazolidine-3-carboxylate
• CAS NO: 135086-52-1
• Molecular Formula: C₂₃H₃₅NO₁₂
• Molecular Weight: 517.5235
• Mol File: 135086-52-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 541.2°C at 760 mmHg
• Flash Point: 281.1°C
• Density: 1.27g/cm³
• Vapor Pressure: 8.91E-12mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: tert-butyl 2,2-dimethyl-4-[(2S,3S,4S,5S,6R)-3,4,5,6-tetraacetoxytetrahydropyran-2-yl]oxazolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2,2-dimethyl-4-[(2S,3S,4S,5S,6R)-3,4,5,6-tetraacetoxytetrahydropyran-2-yl]oxazolidine-3-carboxylate(135086-52-1)
• EPA Substance Registry System: tert-butyl 2,2-dimethyl-4-[(2S,3S,4S,5S,6R)-3,4,5,6-tetraacetoxytetrahydropyran-2-yl]oxazolidine-3-carboxylate(135086-52-1)

Safety Data

• Hazardous Substances Data: 135086-52-1(Hazardous Substances Data)

Upstream product

• 135086-50-9 2,3,5-Tris-O-(trimethylsilyl)-6,7-N,O-isopropylidene-6-<(tert-butoxycarbonyl)amino>-6-deoxy-D-glycero-D-talo-heptano-1,4-lactone 
• 135086-47-4 (R)-4-[(R)-((2S,3S,4S)-5-Hydroxy-3,4-bis-trimethylsilanyloxy-tetrahydro-furan-2-yl)-trimethylsilanyloxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 135086-49-6 (R)-4-[(R)-((2R,3R,4S)-3,4-Dihydroxy-5-oxo-tetrahydro-furan-2-yl)-trimethylsilanyloxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 135086-48-5 (R)-2,2-Dimethyl-4-[(R)-((R)-5-oxo-2,5-dihydro-furan-2-yl)-trimethylsilanyloxy-methyl]-oxazolidine-3-carboxylic acid tert-butyl ester 
• 127997-05-1 6,7-N,O-Isopropylidene-6-<(tert-butoxycarbonyl)amino>-2,3,6-trideoxy-D-arabino-hept-2-enono-1,4-lactone 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 108-24-7 acetic anhydride 
• 135086-51-0 (R)-2,2-Dimethyl-4-((2R,3R,4S,5S,6S)-3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-yl)-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 135086-55-4 1,2,3,4-tetra-O-acetyl-6-deoxy-6-tert-butoxycarbonylamino-α-D-glycero-D-talo-heptopyranuronic acid methyl ester 

Relevant articles and documents

Total Synthesis of 6-Deoxy-6-aminoheptopyranuronic Acid Derivatives

Two enantio couples of terminal C-glycoyranosyl α-amino acids, namely the aminopyranuronic acid, L-9, D-9 and L-10, D-10, hve been synthesized from serine-derived pair L-2, D-2 by exploiting enantiomerically pure butenolide intermediates 3 and 4.The key synthetic steps involved the sequential antiselective cis dihydroxylation of the butenolide double bond and the clean furaose-to-pyranose ring expansion to construct the sugar skeleton with the proper stereochemistry.In our best performance, homogeneous L-9 was prepared from L-2 in four steps and 10 reactions in 20percent overall yield.