128018-18-8Relevant articles and documents
KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic
Mimoto,Imai,Tanaka,Hattori,Kisanuki,Akaji,Kiso
, p. 3088 - 3088 (1991)
HIV-1 protease inhibitors containing allophenylnorstatine (Apns; (2S,3S)-3-amino-2-hydroxy-4-phenyl-butyric acid]-Pro (syn distereomer) as a transition-state mimic were established to be potent and highly selective. Z-Asn-Apns-Pro-NHBu(t) (KNI-102) is the only tripeptide exhibiting substantial anti-HIV activity and may be of minimum size for potent, selective inhibition of HIV protease. Ready availability due to its simple chemical structure and stability should make it valuable for studies of the development of metabolically stable anti-AIDS drugs.
The development of new amine-amide ligands for application in Cu(II)-catalyzed enantioselective Henry reactions
Ao, Chunyan,Men, Jian,Wang, Yang,Shao, Tao,Huang, Yuanyuan,Huo, Junji,Gao, Guowei
, p. 589 - 595 (2016/07/06)
A new type of chiral tertiary amine ligand was designed and derived from l-proline and (R)-BINOL. These new chiral ligands chelated with Cu(II) showed highly catalytic efficiency in enantioselective Henry reactions. Excellent yields (up to 99%) and high enantioselectivities (up to 96% ee) were achieved for aromatic, hetero-aromatic and aliphatic aldehyde substrates, without an additional base additive or the need for air or moisture exclusion.
Stereoselective synthesis of 5-substituted pyrrolo[1,2-c]imidazol-3-ones: Access to annulated chiral imidazol(in)ium salts
Metallinos, Costa,Xu, Shufen
supporting information; experimental part, p. 76 - 79 (2010/03/03)
"Chemical Equation Presented" A two-step synthesis of N-heterocyclic carbene (NHC) precatalysts by diastereoselective or enantioselective lithiation of pyrrolo[1,2-c]imidazol-3-ones followed by POCl3-induced salt formation is described. The res