128018-17-7

Usage

Uses

Used in Pharmaceutical Research:
(L)-N-BENZYLOXYCARBONYL-PROLINE-TERT BUTYLAMIDE is used as a building block for the synthesis of peptide and protein derivatives, contributing to the development of new drugs and pharmaceuticals. Its role in this application is attributed to its structural properties and potential biological activity, which facilitate the creation of novel therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, (L)-N-BENZYLOXYCARBONYL-PROLINE-TERT BUTYLAMIDE is used as a key component in the preparation of various organic compounds and materials. Its unique structure and functional groups enable the synthesis of a diverse range of chemical products, further expanding its utility in research and development.
Used in Enzyme Inhibition Studies:
(L)-N-BENZYLOXYCARBONYL-PROLINE-TERT BUTYLAMIDE is employed as a potential enzyme inhibitor, allowing researchers to study its interactions with specific enzymes and explore its potential as a therapeutic agent for various diseases and conditions.
Used in Receptor Ligand Research:
(L)-N-BENZYLOXYCARBONYL-PROLINE-TERT BUTYLAMIDE is also used in the study of receptor ligands, where it can help researchers understand the binding properties and interactions between ligands and their target receptors, potentially leading to the development of new drugs with improved efficacy and selectivity.

Upstream product

• 75-64-9 tert-butylamine 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 207444-88-0 ((S)-1-{(S)-1-[(1S,2S)-1-Benzyl-3-((S)-2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-hydroxy-3-oxo-propylcarbamoyl]-2-carbamoyl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester 
• 207444-87-9 ((R)-1-{(S)-1-[(1S,2S)-1-Benzyl-3-((S)-2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-hydroxy-3-oxo-propylcarbamoyl]-2-carbamoyl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Optically active complexes of transition metals (RhI, RuII, CoII and NiII) with 2-aminocarbonylpyrrolidine ligands. Selective catalysts for hydrogenation of prochiral olefins

The synthesis and characterization of optically active complexes containing organic amides of the type , , , RuCl2(COD)L>, , X and X, where L = (S)-2-t-butylaminocarbony

Controlling the sign and magnitude of screw-sense preference from the C-terminus of an achiral helical foldamer

The global screw-sense preference of an achiral helical oligomer may be controlled by a single chiral monomer located at one terminus. Remarkably, maximal control is induced in oligomers of the achiral quaternary amino acid Aib by a single C-terminal alaninamide residue, probably because the Ala side chain, though small, is compatible with a 310 helical conformation. The presence or absence of a C-terminal hydrogen bond donor determines the screw sense of the entire oligomer. the Partner Organisations 2014.

Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120

Some HIV-protease inhibitor derivatives having an N- carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta- positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.

Diastereoselective Catalytic Hydrogenation of Nα-Pyruvoyl-(S)-prolinamide

Catlytic hydrogenation of Nα-pyruvoyl-(S)-prolinamide over palladium on charcoal in several solvents resulted in the formation of Nα--(S)-prolinamide in good d.e. up to 77percent.Usefulness of N-isopropyl-(S)-prolinamide