128018-17-7Relevant articles and documents
Optically active complexes of transition metals (RhI, RuII, CoII and NiII) with 2-aminocarbonylpyrrolidine ligands. Selective catalysts for hydrogenation of prochiral olefins
Corma, A.,Iglesias, M.,Pino, C. del,Sanchez, F.
, p. 233 - 246 (1992)
The synthesis and characterization of optically active complexes containing organic amides of the type , , , RuCl2(COD)L>, , X and X, where L = (S)-2-t-butylaminocarbony
Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120
Asagarasu, Akira,Uchiyama, Taketo,Achiwa, Kazuo
, p. 697 - 703 (2007/10/03)
Some HIV-protease inhibitor derivatives having an N- carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta- positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.