1280188-49-9Relevant academic research and scientific papers
5-benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1- ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)
Sunderland, Peter T.,Woon, Esther C. Y.,Dhami, Archana,Bergin, Aoife B.,Mahon, Mary F.,Wood, Pauline J.,Jones, Louise A.,Tully, Sophie R.,Lloyd, Matthew D.,Thompson, Andrew S.,Javaid, Hashim,Martin, Niall M. B.,Threadgill, Michael D.
, p. 2049 - 2059 (2011/05/14)
PARP-2 is a member of the poly(ADP-ribose) polymerase family, with some activities similar to those of PARP-1 but with other distinct roles. Two series of isoquinolin-1-ones were designed, synthesized, and evaluated as selective inhibitors of PARP-2, usin
