1280197-92-3Relevant academic research and scientific papers
Synthesis and c-met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: Identification of 3-(4-acetylpiperazin-1-yl)-5- (3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent
Wang, Yuanxiang,Ai, Jing,Wang, Ying,Chen, Yi,Wang, Lu,Liu, Gang,Geng, Meiyu,Zhang, Ao
, p. 2127 - 2142 (2011/06/17)
By use of an improved synthetic strategy, a series of 3,5-disubstituted and 3,5,7-trisubstituted quinolines were readily prepared. 3,5,7-Trisubstituted quinolines 21a-c, 21l, and 27a-c were identified as the most potent c-Met inhibitors with IC50/su
