128036-33-9Relevant academic research and scientific papers
POTENTIAL ANTIDEPRESSANTS: 3-ARYL-3-(ARYLTHIO)PROPYLAMINES AS SELECTIVE INHIBITORS OF 5-HYDROXYTRYPTAMINE RE-UPTAKE IN THE BRAIN
Valenta, Vladimir,Vlkova, Marie,Valchar, Martin,Dobrovsky, Karel,Polivka, Zdenek
, p. 1525 - 1533 (2007/10/02)
4-(Trifluoromethyl)thiophenol, 2-methylthiophenol, 2-methoxythiophenol, and 1-naphthalene-thiol were transformed by reactions with N,N-dimethyl-3-chloro-3-phenylpropylamine to N,N-dimethyl-3-aryl-3-(arylthio)propylamines IVa-VIIa.These afforded the secondary amines IVb-VIIb by treatment with ethyl chloroformate and by the following hydrolysis and decarboxylation of the primarily formed N-(methyl)N-(ethoxycarbonyl) analogues.Reaction of 1-naphthalenethiol with the 4-toluenesulfonic ester X in situ gave the thiophene analogue VIIIa which was similarly demethylated to VIIIb.Some of the prepared compounds (IVa, IVb, Va, VIIIa) were found to be selective inhibitors of 5-hydroxytryptamine re-uptake in the rat brain synaptosomes which indicates their potential antidepressant activity.
