128036-38-4

Basic information

• Product Name: N-methyl-N-(3-phenyl-3-{[4-(trifluoromethyl)phenyl]sulfanyl}propyl)amine
• Synonyms: N-methyl-N-(3-phenyl-3-{[4-(trifluoromethyl)phenyl]sulfanyl}propyl)amine
• CAS NO: 128036-38-4
• Molecular Formula: C₁₇H₁₈F₃NS
• Molecular Weight: 325.3917296
• Mol File: 128036-38-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methyl-N-(3-phenyl-3-{[4-(trifluoromethyl)phenyl]sulfanyl}propyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(3-phenyl-3-{[4-(trifluoromethyl)phenyl]sulfanyl}propyl)amine(128036-38-4)
• EPA Substance Registry System: N-methyl-N-(3-phenyl-3-{[4-(trifluoromethyl)phenyl]sulfanyl}propyl)amine(128036-38-4)

Safety Data

• Hazardous Substances Data: 128036-38-4(Hazardous Substances Data)

Upstream product

• 825-83-2 4-trifluoromethylbenzenethiol 
• 79130-51-1 3-chloro-N,N-dimethyl-3-phenylpropan-1-amine 
• 136436-87-8 Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine 

Relevant articles and documents

POTENTIAL ANTIDEPRESSANTS: 3-ARYL-3-(ARYLTHIO)PROPYLAMINES AS SELECTIVE INHIBITORS OF 5-HYDROXYTRYPTAMINE RE-UPTAKE IN THE BRAIN

4-(Trifluoromethyl)thiophenol, 2-methylthiophenol, 2-methoxythiophenol, and 1-naphthalene-thiol were transformed by reactions with N,N-dimethyl-3-chloro-3-phenylpropylamine to N,N-dimethyl-3-aryl-3-(arylthio)propylamines IVa-VIIa.These afforded the secondary amines IVb-VIIb by treatment with ethyl chloroformate and by the following hydrolysis and decarboxylation of the primarily formed N-(methyl)N-(ethoxycarbonyl) analogues.Reaction of 1-naphthalenethiol with the 4-toluenesulfonic ester X in situ gave the thiophene analogue VIIIa which was similarly demethylated to VIIIb.Some of the prepared compounds (IVa, IVb, Va, VIIIa) were found to be selective inhibitors of 5-hydroxytryptamine re-uptake in the rat brain synaptosomes which indicates their potential antidepressant activity.