128043-60-7 Usage
General Description
"(3-benzyl-2,4,5-trioxo-imidazolidin-1-yl)-acetic acid ethyl ester" is a chemical compound with a complex structure, containing a benzyl group attached to a imidazolidin-1-yl moiety. It is an ethyl ester derivative of acetic acid and is primarily used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. (3-BENZYL-2,4,5-TRIOXO-IMIDAZOLIDIN-1-YL)-ACETIC ACID ETHYL ESTER may have potential applications in medicinal chemistry, particularly in the development of new drugs targeting specific biological pathways. Additionally, it may also have uses in the production of specialty chemicals and advanced materials. However, as with any chemical, proper handling and safety precautions should be observed when working with "(3-benzyl-2,4,5-trioxo-imidazolidin-1-yl)-acetic acid ethyl ester" to minimize the risk of exposure and ensure safe use.
Check Digit Verification of cas no
The CAS Registry Mumber 128043-60-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,0,4 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 128043-60:
(8*1)+(7*2)+(6*8)+(5*0)+(4*4)+(3*3)+(2*6)+(1*0)=107
107 % 10 = 7
So 128043-60-7 is a valid CAS Registry Number.
128043-60-7Relevant articles and documents
Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase
Rajabi, Mehdi,Mansell, David,Freeman, Sally,Bryce, Richard A.
, p. 1165 - 1171 (2011/04/17)
Novel non-nucleobase-derived inhibitors of the angiogenic enzyme, thymidine phosphorylase, have been identified using molecular modelling, synthesis and biological evaluation. These inhibitors are 2,4,5-trioxoimidazolidines bearing N-(substituted)phenylalkyl groups, together with, in most cases, N′-(CH2)n-carboxylic acid, ester or amide side chains. The best compound from this series is 3-(2,4,5-trioxo-3-phenylethyl- imidazolodin-1-yl)propionamide, with an IC50 of 40 μM against Escherichia coli TP. Molecular modelling suggests that this ligand, when complexed with closed-cleft human TP, would have the phenylalkyl group in the active site region normally occupied by a thymine-containing structure.
PARABANIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
-
, (2008/06/13)
Parabanic acid compound of the formula (I): wherein R is hydrogen or a lower alkyl group, X is hydrogen, an alkyl group, a cycloalkyl group, a lower alkylcycloalkyl group, a phenyl group or a phenalkyl group, and n represents an integer of 1 to 4, exhibit
