128049-46-7

Upstream product

• 106014-83-9 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 119879-94-6 5-(benzyloxy)-2-bromo-N-((tert-butyloxy)carbonyl)-N-(4-(phenylthio)-2-buten-1-yl)aniline 
• 119879-92-4 5-(benzyloxy)-2-bromo-N-((tert-butyloxy)carbonyl)aniline 
• 119879-90-2 5-(Benzyloxy)-2-bromophenylamine 
• 1484-26-0 3-(benzyloxy)aniline 
• 184046-61-5 (2R)-3-acetoxy-2-[4-(benzyloxy)-2-nitrophenyl]propane-1-ol 
• 186144-33-2 Acetic acid (S)-2-(4-benzyloxy-2-nitro-phenyl)-3-methanesulfonyloxy-propyl ester 
• 184046-63-7 Acetic acid (R)-6-benzyloxy-2,3-dihydro-1H-indol-3-ylmethyl ester 
• 186144-35-4 (R)-3-Acetoxymethyl-6-benzyloxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 119879-96-8 6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-vinylindoline 

Downstream Products

• 128049-48-9 (-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline 
• 128049-50-3 (-)-(3R)-1-((tert-butyloxy)carbonyl)-6-hydroxy-3-(((methanesulfonyl)oxy)methyl)indoline 

Relevant academic research and scientific papers

Enzymatic preparation of an optically active precursor of the CC-1065/duocarmycin pharmacophore

Acetylation of 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol with vinyl acetate in the presence of porcine pancreatic lipase gave the (R)-mono-acetate (ee = 92%). The (S)-mono-acetate was obtained via acetylation of the diol followed by transesterificat

Synthesis of N-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI 1, and CI-CDPI 2: CC-1065 functional analogues incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit

Full details of the synthesis of N-(phenylsulfonyl)- and N-((tert-butyloxy)carbonyl)-1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one [N-(phenylsulfonyl)-CI (9) and N-BOC-CI (10)] constituting stable derivatives of the parent cyclopropylcyclohexadienone rin