186144-33-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 184046-61-5 (2R)-3-acetoxy-2-[4-(benzyloxy)-2-nitrophenyl]propane-1-ol 
• 106014-83-9 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol 

Downstream Products

• 186144-35-4 (R)-3-Acetoxymethyl-6-benzyloxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 128049-48-9 (-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(((methanesulfonyl)oxy)methyl)indoline 
• 128049-50-3 (-)-(3R)-1-((tert-butyloxy)carbonyl)-6-hydroxy-3-(((methanesulfonyl)oxy)methyl)indoline 
• 128049-46-7 (-)-(3R)-6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(hydroxymethyl)indoline 
• 184046-63-7 Acetic acid (R)-6-benzyloxy-2,3-dihydro-1H-indol-3-ylmethyl ester 

Relevant academic research and scientific papers

Enzymatic preparation of an optically active precursor of the CC-1065/duocarmycin pharmacophore

Acetylation of 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol with vinyl acetate in the presence of porcine pancreatic lipase gave the (R)-mono-acetate (ee = 92%). The (S)-mono-acetate was obtained via acetylation of the diol followed by transesterificat