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Usage

Uses

Used in Organic Synthesis:
(3-Bromophenyl)(cyclopropyl)sulfane is used as a key intermediate in the synthesis of various organic compounds, leveraging its unique reactivity and structural features to facilitate the creation of complex molecular architectures.
Used in Medicinal Chemistry:
(3-Bromophenyl)(cyclopropyl)sulfane is used as a building block in the design and development of new pharmaceuticals, taking advantage of its potential antioxidant and cytoprotective properties to contribute to the creation of innovative therapeutic agents.
Used in Antioxidant and Cytoprotective Applications:
(3-Bromophenyl)(cyclopropyl)sulfane is used as a compound with potential antioxidant and cytoprotective properties, which may be beneficial in the development of drugs aimed at protecting cells from oxidative stress and other harmful effects.
Further research is necessary to fully comprehend the biological and chemical properties of (3-Bromophenyl)(cyclopropyl)sulfane and to explore its potential applications across different fields.

Upstream product

• 6320-01-0 3-Bromothiophenol 
• 411235-57-9 cyclopropylboronic acid 
• 925430-09-7 tricyclopropylbismuthane 
• 4333-56-6 cyclopropyl bromide 

Downstream Products

• 1020206-37-4 2-(3-(cyclopropylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 19433-09-1 1-bromo-3-(cyclopropylsulfonyl)benzene 

Relevant academic research and scientific papers

Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid

The copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid is reported. The procedure operates under simple conditions to afford the corresponding aryl cyclopropyl sulfides in moderate to excellent yields. The reaction tolerates substitution in ortho-, meta- and para-substitution as well as electron-donating and electron-withdrawing groups. The S-cyclopropylation of a thiophenol was also accomplished using potassium cyclopropyl trifluoroborate.

First use of an organobismuth reagent in C(sp3)–S bond formation: Access to aryl cyclopropyl sulfides via copper-catalyzed S–Cyclopropylation of thiophenols using tricyclopropylbismuth

The direct S-cyclopropylation of thiophenols using tricyclopropylbismuth is reported. The reaction is catalyzed by copper(II) acetate and operates under mild conditions to afford the corresponding aryl cyclopropyl sulfides in moderate to good yields. This reaction represents the first use of an organobismuth reagent in C(sp3)–S bond formation.

ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS

Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R5, R6, R8, R9, R11, X1, and X2 are as defined herein, as compounds for treatment and prevention of cancer and proliferative diseases and disorders.

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

LXR MODULATORS

The present invention provides compounds of Formula I and Formula II: or pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXRs), and compositions comprising any of such novel compounds and methods of use thereof. These compounds are useful as medicaments for treatment and/or prophylaxis for diseases or conditions related to activity of LXRs.

2-PYRIDONE COMPOUNDS

A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.