128093-94-7

Upstream product

• 143-33-9 sodium cyanide 
• 100-50-5 3-Cyclohexene-1-carboxaldehyde 
• 7732-18-5 water 
• 773837-37-9 sodium cyanide 
• 613-90-1 benzoyl cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 85906-00-9 cyclohex-3-enyl(trimethylsilyloxy)acetonitrile 

Downstream Products

• 1373018-95-1 cyclohex-3-enyl(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)methanol 
• 1373018-73-5 cyclohex-3-enyl(5-methyl-4H-1,2,4-triazol-3-yl)methanol 
• 1373018-94-0 cyclohex-3-enyl(5-phenyl-4H-1,2,4-triazol-3-yl)methanol 
• 1373018-96-2 cyclohex-3-enyl(5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)methanol 
• 57230-07-6 2-amino-1-cyclohex-3-enyl-ethanol 

Relevant academic research and scientific papers

A single-step, mild, neutral, catalyst-free method for cyanohydrin synthesis

A wide variety of carbonyl compounds can be transformed to their corresponding cyanohydrins in a single step using a dimethyl sulfoxide (DMSO)-water system in excellent yields (75-94%). The major advantages of this system are that the reaction conditions are mild and neutral; the reaction proceeds without catalyst and gives the corresponding cyanohydrins in short time (15-120 min).

Access to β-Ketonitriles through Nickel-Catalyzed Carbonylative Coupling of α-Bromonitriles with Alkylzinc Reagents

Herein, we report a nickel-catalyzed carbonylative coupling of α-bromonitriles and alkylzinc reagents with near stoichiometric carbon monoxide to give β-ketonitriles in good yields. The reaction is catalyzed by a readily available and stable nickel(II) pincer complex. The developed protocol tolerates substrates bearing a variety of functional groups, which would be problematic or incompatible with previous synthetic methods. Additionally, we demonstrate the suitability of the method for carbon isotope labeling by the synthesis of 13C-labeled β-ketonitriles and their transformation into isotopically labeled heterocycles.

Novel 4H-1,2,4-triazol-3-yl cycloalkanols as potent antitubercular agents

Enzymes of shikimate pathway, dehydroquinase and shikimate kinase represent comparatively newer targets for antitubercular research. Molecular hybridization approach was implemented by integrating the essential features of inhibitors acting on these enzymes of shikimate pathway. Considering the flexibility of alicyclic ring of reported dehydroquinase (DHQ) inhibitors and triazole ring, key feature of the virtual hits of Mtb shikimate kinase, a series of structurally novel, substituted 4H-1,2,4-triazol-3-yl cycloalkanols were designed as antimycobacterial agents. Docking studies of the molecules was carried out on the enzyme DHQ. All the synthesized compounds exhibited promising activity (MIC 0.59-15.5 μg/ml) against H37Rv strains of Mycobacterium tuberculosis using resazurin microtiter assay. Five of the evaluated compounds exhibit MIC 50 values indicate compounds are non-toxic, with selectivity indices >28. These compounds could serve as leads for further optimization to obtain novel antimycobacterial agents.

Enzymatic Preparation of Optically Active Cyanohydrin Acetates

A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.

Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity

Hypoglycemic oxazolidine-2,4-diones, substituted at the 5-position with a (C5 -C9) unsaturated monocyclic, saturated bicyclic or unsaturated bicyclic hydrocarbon radical; methods for their preparation; and method for their use in the