128094-99-5Relevant academic research and scientific papers
Alkylation of 3,5-Dimethylisothiazole. A Regioselective Synthesis of 5-Alkyl-3-methylisothiazoles
Alberola, Angel,Andres, Celia,Casado, Jose L.,Gonzalez, Alfonso,Pedrosa, Rafael
, p. 617 - 624 (2007/10/02)
3,5-Dimethylisothiazole reacts sequentially with lithiumdiisopropylamide (molar ratio 1:1) and alkyl halides (in excess) affording 5-alkyl-3-methylisothiazoles in excellent yields.When a two-fold excess of base is used, a mixture of 5-monoalkylated and 3,5-dialkylated products is obtained.Sodium amide was tried as deprotonating agent, but the yield in final products was lower.
