24260-24-0

Upstream product

• 113234-28-9 3,5-dimethyl-4-isothiazolylmagnesium iodide 
• 20067-15-6 5-iodo-3-methylisothiazole 
• 13061-96-6 dihydroxy-methyl-borane 
• 7299-55-0 pent-3-yn-2-one 

Downstream Products

• 128094-99-5 3-Methyl-5-phenethyl-isothiazole 
• 128095-03-4 3,5-Diphenethyl-isothiazole 

Relevant academic research and scientific papers

BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF

PROBLEM TO BE SOLVED: To provide compounds with excellent antimycotic activity against Trichophyton. SOLUTION: The invention provides pharmaceuticals comprising biaryl derivatives represented by general formula (I) or salts thereof, where ring A is optionally substituted phenyl or the like; Q is CH2 or the like; X1, X2 and X3 are CR1 or the like; and Y is CH or N. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

CARM1 INHIBITORS AND USES THEREOF

Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula: wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARMl activity. Methods of using the compounds for treating CARMl -mediated disorders are also described.

3,5-DIMETHYL-4-ISOTHIAZOLYLMAGNESIUM IODIDE AND ITS REACTIONS WITH SOME ELECTROPHILIC REAGENTS

As a route to 4-alkyl-, 4-alkenyl- and 4-hydroxyalkyl-isothiazoles, 3,5-dimethyl-4-isothiazolylmagnesium iodide has been obtained, and its reactions with organic halides, oxocompounds and nitriles have been studied.