128113-77-9

Basic information

• Product Name: (1S,1'S)-N-(1'-phenylethyl)-1-(2''-isopropoxy-3'',4''-dimethoxyphenyl)ethylamine
• Synonyms: (1S,1'S)-N-(1'-phenylethyl)-1-(2''-isopropoxy-3'',4''-dimethoxyphenyl)ethylamine
• CAS NO: 128113-77-9
• Molecular Weight: 343.466
• Mol File: 128113-77-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,1'S)-N-(1'-phenylethyl)-1-(2''-isopropoxy-3'',4''-dimethoxyphenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,1'S)-N-(1'-phenylethyl)-1-(2''-isopropoxy-3'',4''-dimethoxyphenyl)ethylamine(128113-77-9)
• EPA Substance Registry System: (1S,1'S)-N-(1'-phenylethyl)-1-(2''-isopropoxy-3'',4''-dimethoxyphenyl)ethylamine(128113-77-9)

Safety Data

• Hazardous Substances Data: 128113-77-9(Hazardous Substances Data)

Upstream product

• 128113-82-6 (1S,1'S)-N-(1'-phenylethyl)-1-<2''-(methylamino)phenyl>ethylamine 
• 551-93-9 2-aminoacetophenone 
• 1859-75-2 o-(methylamino)acetophenone 
• 5396-18-9 2'-hydroxy-3',4'-dimethoxyacetophenone 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 128113-84-8 1-(2-isopropoxy-3,4-dimethoxyphenyl)-1-ethanone 

Downstream Products

• 128113-96-2 N-(2,4-Dinitro-phenylsulfanyl)-N-[(S)-1-(2-isopropoxy-3,4-dimethoxy-phenyl)-ethyl]-4-methyl-benzenesulfonamide 
• 121082-96-0 (S)-1-(2'-isopropoxy-3',4'-dimethoxyphenyl)ethylamine 

Relevant articles and documents

Chiral Building Blocks for the Synthesis of Nitrogen-Containing Natural Products, 5. The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones

An efficient two-step procedure for the synthesis of enantiomerically pure, benzene nucleus-substituted 1-phenylethylamines 1 is described, with predictable absolute configuration at the stereogenic center: Imine formation from the substituted acetophenones 6 with (S)- or (R)-1-phenylethylamine and subsequent hydrogenation of the resulting Schiff bases 8 over Raney nickel leads to the secondary amines 9 and 10 in high diastereoselectivities.These dibenzylamines are cleaved regioselectively, usually next to the less substituted aromatic ring, giving the desired chiral 1-phenylethylamines 1 in high yields and enantiomeric purities.Scope and limitations of this new and facile approach to the versatile building blocks 1 are reported.