128129-42-0

Usage

General Description

3-Methoxysampangine is a natural organic compound found in the roots and stems of certain plant species, particularly in the genus Aglaia. It belongs to the class of indole alkaloids and is known for its potential anti-cancer and anti-tumor activities. Studies have shown that 3-Methoxysampangine may inhibit the growth of cancer cells by inducing apoptosis and inhibiting cell proliferation. Additionally, it has been found to possess antimicrobial and anti-inflammatory properties. Its chemical structure and biological activities make 3-Methoxysampangine a promising candidate for further research and potential pharmaceutical development.

InChI:InChI=1/C16H10N2O2/c1-20-12-8-18-14-9-4-2-3-5-10(9)16(19)15-13(14)11(12)6-7-17-15/h2-8H,1H3

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 143858-52-0 4'-methoxycleistopholine 
• 67-56-1 methanol 
• 161237-42-9 3-bromo-7H-naphtho[1,2,3-i,j][2,7]naphthyridin-7-one 

Relevant academic research and scientific papers

Studies on Methoxylation in the 7H-Naphtho[1,2,3-i,j] [2,7]naphthyridin-7-one System

Studies on methoxylation in the 7H-naphtho[1,2,3-i,j][2,7]naphthyridin-7-one (sampangine) system represented by 3-bromo- and 4-bromosampangine as well as sampangine itself are described. We have found that regioselectivity of nucleophilic substitution in the sampangine system can be directed by reaction conditions. Under kinetic control (lower temperatures) substitution at C-4 is the predominant reaction, regardless of whether 3-bromo or 4-bromosampangine were used. At higher temperatures, when the reaction is thermodynamically controlled, substitution of the bromine atom at C-3 predominates. This is the first reported example of nucleophilic substitution in ring A of the 7H-naphtho [1,2,3-i,j][2,7]naphthyridin-7-one system.

Compounds and compositions useful as antifungal and antimycobacterial agents

New analogs of sampangine and cleistopholine, compositions and methods of preparation thereof, method of treating fungal and mycobacterial infections. The compounds have the general formula: STR1 where the R1, R2, and R5 groups are defined herein.

Copyrine alkaloids: Synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines

Several A- and B-ring-substituted sampangines were synthesized and evaluated for antifungal and antimycobacterial activity against AIDS-related opportunistic infection pathogens. Electrophilic halogenation provided a channel for structural elaboration of