128129-42-0

Basic information

• Product Name: 3-Methoxysampangine
• Synonyms: 3-Methoxysampangine
• CAS NO: 128129-42-0
• Molecular Formula: C16H10N2O2
• Molecular Weight: 262.267
• Mol File: 128129-42-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 525.6°C at 760 mmHg
• Flash Point: 271.7°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 3.87E-11mmHg at 25°C
• Refractive Index: 1.717
• CAS DataBase Reference: 3-Methoxysampangine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxysampangine(128129-42-0)
• EPA Substance Registry System: 3-Methoxysampangine(128129-42-0)

Safety Data

• Hazardous Substances Data: 128129-42-0(Hazardous Substances Data)

Usage

General Description

3-Methoxysampangine is a natural organic compound found in the roots and stems of certain plant species, particularly in the genus Aglaia. It belongs to the class of indole alkaloids and is known for its potential anti-cancer and anti-tumor activities. Studies have shown that 3-Methoxysampangine may inhibit the growth of cancer cells by inducing apoptosis and inhibiting cell proliferation. Additionally, it has been found to possess antimicrobial and anti-inflammatory properties. Its chemical structure and biological activities make 3-Methoxysampangine a promising candidate for further research and potential pharmaceutical development.

InChI:InChI=1/C16H10N2O2/c1-20-12-8-18-14-9-4-2-3-5-10(9)16(19)15-13(14)11(12)6-7-17-15/h2-8H,1H3

Upstream product

• 67-56-1 methanol 
• 161237-42-9 3-bromo-7H-naphtho[1,2,3-i,j][2,7]naphthyridin-7-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 143858-52-0 4'-methoxycleistopholine 

Relevant articles and documents

Studies on Methoxylation in the 7H-Naphtho[1,2,3-i,j] [2,7]naphthyridin-7-one System

Studies on methoxylation in the 7H-naphtho[1,2,3-i,j][2,7]naphthyridin-7-one (sampangine) system represented by 3-bromo- and 4-bromosampangine as well as sampangine itself are described. We have found that regioselectivity of nucleophilic substitution in the sampangine system can be directed by reaction conditions. Under kinetic control (lower temperatures) substitution at C-4 is the predominant reaction, regardless of whether 3-bromo or 4-bromosampangine were used. At higher temperatures, when the reaction is thermodynamically controlled, substitution of the bromine atom at C-3 predominates. This is the first reported example of nucleophilic substitution in ring A of the 7H-naphtho [1,2,3-i,j][2,7]naphthyridin-7-one system.

Copyrine alkaloids: Synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines

Several A- and B-ring-substituted sampangines were synthesized and evaluated for antifungal and antimycobacterial activity against AIDS-related opportunistic infection pathogens. Electrophilic halogenation provided a channel for structural elaboration of