128140-93-2Relevant academic research and scientific papers
The Highly Efficient Suzuki–Miyaura Cross-Coupling of (Hetero)aryl Chlorides and (Hetero)arylboronic Acids Catalyzed by “Bulky-yet-Flexible” Palladium–PEPPSI Complexes in Air
Ouyang, Jia-Sheng,Li, Yan-Fang,Huang, Fei-Dong,Lu, Dong-Dong,Liu, Feng-Shou
, p. 371 - 375 (2017/12/15)
A series of Pd–PEPPSI complexes were designed and synthesized. The relationship between catalyst structure and properties was systematically investigated. It was revealed that “bulky-yet-flexible” C3 bearing ancenaphthyl backbone was a highly efficient precatalyst and could be successfully employed in Suzuki–Miyaura reactions of (hetero)aryl chlorides with (hetero)arylboronic acids at a low palladium loading in the presence of a weak inorganic base in air.
Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities
Son, Jong-Keun,Zhao, Long-Xuan,Basnet, Arjun,Thapa, Pritam,Karki, Radha,Na, Younghwa,Jahng, Yurngdong,Jeong, Tae Cheon,Jeong, Byeong-Seon,Lee, Chong-Soon,Lee, Eung-Seok
, p. 675 - 682 (2008/09/20)
For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities.
CONVENIENT SYNTHESIS OF VARIOUS TERHETEROCYCLIC COMPOUNDS BY Pd(O)-CATALYZED COUPLING REACTIONS
Gronowitz, Salo,Peters, Dan
, p. 645 - 658 (2007/10/02)
Various terheterocyclic compounds containing thiophene, furan, selenophene, pyridine and thiazole rings have been obtained by the Pd(PPh3)4-catalyzed coupling of dihalo-substituted heterocyclic compounds with heterocyclic boronic acids, using sodium bicar
