128156-58-1

Basic information

• Product Name: 4-Benzoxazolecarboxylic acid, 2-(4-methoxyphenyl)-, methyl ester
• CAS NO: 128156-58-1
• Molecular Formula: C16H13NO4
• Molecular Weight: 283.284
• Mol File: 128156-58-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-Benzoxazolecarboxylic acid, 2-(4-methoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzoxazolecarboxylic acid, 2-(4-methoxyphenyl)-, methyl ester(128156-58-1)
• EPA Substance Registry System: 4-Benzoxazolecarboxylic acid, 2-(4-methoxyphenyl)-, methyl ester(128156-58-1)

Safety Data

• Hazardous Substances Data: 128156-58-1(Hazardous Substances Data)

Upstream product

• 172462-96-3 Methyl 3-hydroxy-2-(N-4-methoxybenzoyl)aminobenzoate 
• 24057-28-1 pyridinium p-toluenesulfonate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 548-93-6 3-hydroxyanthranilic acid 

Relevant articles and documents

BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Benzamide analogs useful as PARP (ADP-ribosyltransferase, ADPRT) DNA repair enzyme inhibitors

A range of 3-oxybenzamide compounds and related quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed include 3-benzyloxybenzamides, 3-oxybenzamides in which a chain of 5 or more methylene groups terminate in a halogen atom or in a purin-9-yl moiety, certain benzoxazole-4-carboxamide compounds and certain quinazolinone compounds. In formula X and Y together may form a bride -X-Y- that represents the grouping (a), (b) or (c )wherein R5 is H, alkyl, aryl or aralkyl.