128164-79-4

Upstream product

• 41865-47-8 2-<(2-tetrahydropyranyl)oxy>-2-phenylacetonitrile 

Downstream Products

• 122683-26-5 3-[3-(1,1-diphenyl-1-hydroxymethyl)-1,2,4-thiadiazol-5-yl]quinuclidine 
• 122683-24-3 3-<3-(1-hydroxy-1-phenylmethyl)-1,2,4-thiadiazol-5-yl>quinuclidine 
• 122683-25-4 3-(3-benzoyl-1,2,4-thiadiazol-5-yl)quinuclidine 
• 122684-46-2 3-<1-phenyl-1-(tetrahydropyranyloxy)methyl>-5-chloro-1,2,4-thiadiazole 

Relevant academic research and scientific papers

THIADIAZOLES USEFUL IN THE TREATMENT OF SENILE DEMENTIA

A class of novel thiadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophilicity, or a hydrocarbon substituent; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses, and are also of benefit in the treatment of severe painful conditions.

Synthesis and muscarinic activities of 1,2,4-thiadiazoles

A series of novel 1,2,4-thiadiazoles bearing a mono- or bicyclic amine at C5 were prepared. Quinuclidine and 1-azabicyclo[2.2.1]heptane derivatives were synthesized by reaction of the lithium enolate of the 3-methoxycarbonyl compounds followed by ester hy