1281860-72-7

Upstream product

• 101251-18-7 7-chloro-5-methyl-2-(methylthio)[1,2,4]triazolo[ 1,5-a]pyrimidine 
• 40775-78-8 7-hydroxy-5-methyl-2-methylthio-(1,2,4)-triazolo[1,5-a]pyrimidine 

Downstream Products

• 1281860-73-8 C₁₄H₁₁F₄N₅O₂S 
• 1281860-92-1 2-(ethyloxy)-N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 

Relevant academic research and scientific papers

ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE

Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.