128189-49-1Relevant academic research and scientific papers
The Cyclisation of Benzylaminonitriles. Part 7. Regiospecific Formation of Methoxy-substituted Isoquinolin-4-ones using Methylthio Activating Groups
Gavin, James P.,Waigh, Roger D.
, p. 503 - 508 (2007/10/02)
Cyclisation of 3,4-dialkoxybenzylaminoacetonitriles proceeds preferentially through a spiro intermediate.A 2,3-dialkoxy analogue will therefore normally give a 5,6-dialkoxyisoquinolinone after rearrangement and 7,8-dimethoxy substitution is not obtained.I
