1281895-44-0

Basic information

• Product Name: (+)-1-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]-1,2-hydrazinedicarboxylic acid 1,2-di-tert-butylester
• Synonyms: (+)-1-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]-1,2-hydrazinedicarboxylic acid 1,2-di-tert-butylester
• CAS NO: 1281895-44-0
• Molecular Weight: 482.531
• Mol File: 1281895-44-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-1-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]-1,2-hydrazinedicarboxylic acid 1,2-di-tert-butylester(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-1-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]-1,2-hydrazinedicarboxylic acid 1,2-di-tert-butylester(1281895-44-0)
• EPA Substance Registry System: (+)-1-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]-1,2-hydrazinedicarboxylic acid 1,2-di-tert-butylester(1281895-44-0)

Safety Data

• Hazardous Substances Data: 1281895-44-0(Hazardous Substances Data)

Upstream product

• 168165-94-4 methyl 3-(3,4-dimethoxyphenyl)-2-methyl-3-oxopropanoate 
• 870-50-8 di-tert-butyl (E)-azodicarboxylate 
• 870-50-8 di-tert-butyl-diazodicarboxylate 
• 74053-93-3 methyl 3-(3,4-dimethoxyphenyl)-3-oxopropionate 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 1426847-82-6 (S)-benzyl 2-(1-(3,4-dimethoxyphenyl)-3-methoxy-2-methyl-1,3-dioxopropan-2-yl)hydrazinecarboxylate 
• 1426847-83-7 (+)-2-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]hydrazinecarboxylic acid benzyl ester 
• 302-53-4 S(-)-carbidopa 

Relevant articles and documents

Chiral lithium binaphtholate for enantioselective amination of acyclic α-alkyl-β-keto esters: Application to the total synthesis of L-carbidopa

A chiral lithium binaphtholate catalyzes the enantioselective amination of α-alkyl-β-keto esters with azodicarboxylates to produce optically active α,α-disubstituted α-amino acid derivatives in high yields and with good to high enantioselectivities. A stoichiometric amount of lithium hydroxide efficaciously improved both the reactivity and enantioselectivity of amination. The resulting aminated product is readily convertible to L-carbidopa.

Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination

A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate indu