128192-10-9

Upstream product

• 128192-03-0 5-(phenylthio)-2,4-dimethyl-3-phenyl-2-cyclopenten-1-one 
• 50396-96-8 E-4-hexen-3-one 
• 100-52-7 benzaldehyde 
• 673-32-5 1-Phenylprop-1-yne 
• 55673-53-5 but-2-enoic acid phenyl ester 
• 217076-66-9 (E,E)-1-phenyl-2,5-dimethyl-1,4-pentadien-3-one 
• 128191-96-8 (Z)-2-Chloro-2-methyl-3-phenyl-pent-3-enoic acid ethyl ester 
• 1616-66-6 ethyl 2-methyl-3-phenyl-2-pentenoate 

Relevant academic research and scientific papers

Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co–Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C?C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis. (Figure presented.).

Synthesis of cyclopentenols and cyclopentenones via nickel-catalyzed reductive cycloaddition

Strategies for the reductive cycloaddition of enals or enoates with alkynes have been developed. The enal-alkyne cycloaddition directly affords cyclopentenols, whereas the enoate-alkyne cycloaddition affords the analogous cyclopentenones. The mechanism of

A general and regioselective synthesis of cyclopentenone derivatives through nickel(0)-mediated [3 + 2] cyclization of alkenyl fischer carbene complexes and internal alkynes

A broad range of substituted 2-cyclopentenone derivatives 3-6 are synthesized by the nickel-(O)-mediated [3 + 2] cyclization reaction of chromium alkenyl(methoxy)carbene complexes 1 and internal alkynes 2. The reaction takes place with complete regioselec