128200-32-8

Basic information

• Product Name: 5-nitro-1H-indole-3-carboxaMide
• Synonyms: 5-nitro-1H-indole-3-carboxaMide
• CAS NO: 128200-32-8
• Molecular Formula: C9H7N3O3
• Molecular Weight: 205.17018
• Mol File: 128200-32-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-nitro-1H-indole-3-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-1H-indole-3-carboxaMide(128200-32-8)
• EPA Substance Registry System: 5-nitro-1H-indole-3-carboxaMide(128200-32-8)

Safety Data

• Hazardous Substances Data: 128200-32-8(Hazardous Substances Data)

Usage

General Description

5-nitro-1H-indole-3-carboxamide is a chemical compound with the molecular formula C9H7N3O3. It is a nitro-substituted derivative of indole and is commonly used in organic synthesis and pharmaceutical research. 5-nitro-1H-indole-3-carboxaMide has a nitro group attached to the 5-position of the indole ring and a carboxamide group at the 3-position. It is a yellow to orange solid at room temperature and is sparingly soluble in water. 5-nitro-1H-indole-3-carboxamide has been studied for its potential biological activities, such as its antiproliferative and anticancer properties, and it is also used as a building block for the synthesis of various pharmaceutical compounds. However, it is important to handle this chemical with care as it may be harmful if ingested or inhaled, and it can cause skin and eye irritation.

Upstream product

• 101832-10-4 2,2,2-trifluoro-1-(5-nitro-1H-indol-3-yl)ethanone 
• 6958-37-8 5-nitro-1H-indole-3-carboxylic acid 
• 1058740-61-6 5-nitro-1H-indole-3-carbonyl chloride 
• 6146-52-7 5-nitroindole 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 7147-14-0 5-nitro-1H-indole-3-carbonitrile 

Relevant articles and documents

AMINO COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an amino substituent (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

Spirocyclic compounds incorporating five-membered rings with two heteroatoms for treating psychotic disorders, etc.

The present invention provides a compound of formula I or a salt or prodrug thereof: STR1 wherein the dotted line represents an optional chemical bond in one of the two possible positions; A represents a group of formula II: STR2 in which R1 represents hydrogen, hydroxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, benzyloxy, hydroxy (C1-6)alkyl, halogen, amino, cyano, nitro, --CONR6 R7 or --SO2 NR6 R7, in which R6 and R7 independently represent hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; R2 represents hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy or C1-6 alkylcarbonyl; V represents nitrogen, --CH or --C--; and W represents oxygen, sulphur or --NR8, in which R8 represents hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; two of X, Y and Z are the same or different and each represents oxygen, sulphur or nitrogen; and the remaining group X, Y or Z is carbon, or Y is carbonyl (C=O); and Q is the residue of an azacyclic or azabicyclic ring system; which compounds are useful in the treatment of psychotic disorders (e.g. schizophrenia and mania); anxiety; alcohol or drug withdrawal or dependence; pain; gastric stasis; gastric dysfunction (such as occurs with dyspepsia, peptic ulcer, reflux oesophagitis and flatulence); migraine, nausea and vomiting; movement disorders; and presenile and senile dementia.