1282034-75-6Relevant academic research and scientific papers
Rational design of β-sheet ligands against Aβ42- induced toxicity
Hochdoerffer, Katrin,Maerz-Berberich, Julia,Nagel-Steger, Luitgard,Epple, Matthias,Meyer-Zaika, Wolfgang,Horn, Anselm H.C.,Sticht, Heinrich,Sinha, Sharmistha,Bitan, Gal,Schrader, Thomas
, p. 4348 - 4358 (2011/06/21)
A β-sheet-binding scaffold was equipped with long-range chemical groups for tertiary contacts toward specific regions of the Alzheimer's Aβ fibril. The new constructs contain a trimeric aminopyrazole carboxylic acid, elongated with a C-terminal binding si
