1282040-37-2Relevant academic research and scientific papers
Gold-Catalyzed Formal Dehydro-Diels–Alder Reactions of Ene-Ynamide Derivatives Bearing Terminal Alkyne Chains: Scope and Mechanistic Studies
Zhao, Qing,León Rayo, David Fabian,Campeau, Dominic,Daenen, Martin,Gagosz, Fabien
, p. 13603 - 13607 (2018)
A new protocol for the synthesis of a variety of N-containing aromatic heterocycles by a formal gold-catalyzed dehydro-Diels–Alder reaction of ynamide derivatives has been developed. Deuterium-labeling experiments and kinetic studies support the involvement of a dual gold catalysis mechanism in which a gold acetylide moiety adds onto an aurated keteneiminium.
NaBArF4-Catalyzed Oxidative Cyclization of 1,5- and 1,6-Diynes: Efficient and Divergent Synthesis of Functionalized γ- and δ-Lactams
Zhu, Bo-Han,Wang, Cai-Ming,Su, Hong-Yu,Ye, Long-Wu
supporting information, p. 58 - 62 (2019/01/04)
An efficient NaBArF4-catalyzed oxidative cyclization of readily available 1,5- and 1,6-diynes has been developed. Importantly, this transition metal-free oxidative catalysis proceeds via a presumable Lewis acid-catalyzed SN2’ pathway, which is distinct from the relevant oxidative rhodium and gold catalysis. This method leads to the facile and practical construction of a diverse range of synthetically useful γ- and δ-lactams in mostly good to excellent yields with broad substrate scope.
Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines
Garcia, Pierre,Evanno, Yannick,George, Pascal,Sevrin, Mireille,Ricci, Gino,Malacria, Max,Auber, C. Torinne,Gandon, Vincent
supporting information; experimental part, p. 2030 - 2033 (2011/06/23)
Bimolecular cobalt-catalyzed [2+2+2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion.
