1282041-33-1

Basic information

• Product Name: (E)-5,7-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one
• Synonyms: (E)-5,7-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one
• CAS NO: 1282041-33-1
• Molecular Weight: 312.322
• Mol File: 1282041-33-1.mol

Chemical Properties

• CAS DataBase Reference: (E)-5,7-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5,7-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one(1282041-33-1)
• EPA Substance Registry System: (E)-5,7-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one(1282041-33-1)

Safety Data

• Hazardous Substances Data: 1282041-33-1(Hazardous Substances Data)

Upstream product

• 54107-66-3 5,7-dimethoxy-4-chromanone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 854678-45-8 β-(3,5-dimethoxyphenoxy)propionic acid 
• 59887-91-1 5,7-dimethoxy-4H-chromen-4-one 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 500-99-2 3,5-dimethoxyphenol 

Relevant articles and documents

Novel homoisoflavanone derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating ischemic brain damage and multiple sclerosis containing the same as an active ingredient

The present invention relates to: a homoisoflavanone compound; a manufacturing method thereof; and a pharmaceutical composition for preventing or treating ischemic brain damage and multiple sclerosis containing the homoisoflavanone compound as an active i

Anti-inflammatory activities of selected synthetic homoisoflavanones

Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti-inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a-4d) were synthesised from the corresponding substituted phenols.1H-and 13C-NMR data together with high-resolution mass spectroscopy data were employed to elucidate the structures. Anti-inflammatory activity was determined in mice with acute croton oil-induced auricular dermatitis. Invitro cytotoxicity was tested against a Chinese hamster ovarian cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide (MTT) assay. Compound 4a exhibited a tendency to inhibit oedema in a dose-dependent manner after 3 and 6 h of treatment. Compounds 4b-4d also inhibited oedema, although a clear dose-response relationship was not observed. Compounds 4a-4c were found to be less cytotoxic than compound 4d. Compound 4b was the least cytotoxic. Compounds 4a-4d exhibited anti-inflammatory activity and varying levels of cytotoxicity.

Synthesis and NMR elucidation of homoisoflavanone analogues

A series of five homoisoflavanone analogues have been synthesized from the corresponding 3,5-methoxy phenols via chroman-4-one in three steps. The complete NMR elucidation of these homoisoflavanone analogues is reported. The use of 2D NMR techniques (COSY, NOESY, HSQC and HMBC) proved to be very useful tools in the elucidation of homoisoflavanone analogues. The homoisoflavanone analogues exhibit an AA0BB0 spin pattern in the ring B of the homoisoflavanone. These homoisoflavanone analogues are potential antifungal and anti-inflammatory agents. Springer Science+Business Media, LLC 2010.