854678-45-8

Basic information

• Product Name: 3-(3,5-dimethoxyphenoxy)propanoic acid
• Synonyms: 3-(3,5-dimethoxyphenoxy)propanoic acid
• CAS NO: 854678-45-8
• Molecular Formula: C₁₁H₁₄O₅
• Molecular Weight: 226.22586
• Mol File: 854678-45-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(3,5-dimethoxyphenoxy)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-dimethoxyphenoxy)propanoic acid(854678-45-8)
• EPA Substance Registry System: 3-(3,5-dimethoxyphenoxy)propanoic acid(854678-45-8)

Safety Data

• Hazardous Substances Data: 854678-45-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(3,5-Dimethoxyphenoxy)propanoic acid is used as a starting material for the synthesis of biologically active compounds due to its versatile chemical structure and potential therapeutic effects.
Used in Drug Development:
DMPA is used as a building block for the preparation of potential drug candidates, leveraging its anti-inflammatory and anti-thrombotic properties to contribute to the development of new medications.
Used in Cardiovascular Disease Treatment:
3-(3,5-Dimethoxyphenoxy)propanoic acid is studied for its potential use in the treatment of cardiovascular diseases, given its ability to modulate processes that may contribute to such conditions.
Used in Anticancer Therapy:
DMPA is being investigated as an anti-cancer agent, with its potential to be incorporated into cancer treatment regimens due to its observed biological activities.

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 16987-03-4 sodium 3-chloroproanoate 
• 107-94-8 chloropropionic acid 
• 590-92-1 3-Bromopropionic acid 

Downstream Products

• 27181-65-3 (E)-5,7-dimethoxy-3-(4-methoxybenzylidene)-4-chromanone 
• 1282041-32-0 (E)-5,7-dimethoxy-3-(benzylidene)chroman-4-one 
• 1282041-33-1 (E)-5,7-dimethoxy-3-(4'-hydroxybenzylidene)chroman-4-one 
• 1282041-34-2 (E)-5,7-dimethoxy-3-(4-chlorobenzylidene)-4-chromanone 
• 59887-91-1 5,7-dimethoxy-4H-chromen-4-one 
• 54107-66-3 5,7-dimethoxy-4-chromanone 

Relevant articles and documents

HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF

The present application is directed to compounds of Formula (I): compounds of Formula (II): compounds of Formula (III): and compounds of Formula (IV): compositions comprising these compounds and their uses, for example as medicaments and /or diagnostics.

The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae (sensu APGII)

Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, and retinopathy of prematurity, which are major causes of blindness. Small molecule antiangiogenic

Anti-inflammatory activities of selected synthetic homoisoflavanones

Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti-inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a-4d) were synthesised from the corresponding substituted phenols.1H-and 13C-NMR data together with high-resolution mass spectroscopy data were employed to elucidate the structures. Anti-inflammatory activity was determined in mice with acute croton oil-induced auricular dermatitis. Invitro cytotoxicity was tested against a Chinese hamster ovarian cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide (MTT) assay. Compound 4a exhibited a tendency to inhibit oedema in a dose-dependent manner after 3 and 6 h of treatment. Compounds 4b-4d also inhibited oedema, although a clear dose-response relationship was not observed. Compounds 4a-4c were found to be less cytotoxic than compound 4d. Compound 4b was the least cytotoxic. Compounds 4a-4d exhibited anti-inflammatory activity and varying levels of cytotoxicity.

Synthesis and NMR elucidation of homoisoflavanone analogues

A series of five homoisoflavanone analogues have been synthesized from the corresponding 3,5-methoxy phenols via chroman-4-one in three steps. The complete NMR elucidation of these homoisoflavanone analogues is reported. The use of 2D NMR techniques (COSY, NOESY, HSQC and HMBC) proved to be very useful tools in the elucidation of homoisoflavanone analogues. The homoisoflavanone analogues exhibit an AA0BB0 spin pattern in the ring B of the homoisoflavanone. These homoisoflavanone analogues are potential antifungal and anti-inflammatory agents. Springer Science+Business Media, LLC 2010.

Isomerisation of 3-Benzylidene-4-chromanones in Presence of Alkali

3-Benzylidene-4-chromanones (Ia-d) having 7-methoxy, 7-benzyloxy- or 5,7-dimethoxy groupings in ring-A undergo alkali isomerisation to yield both the corresponding 3-benzyl-4-chromones (IIa-d) and 3-methylflavones (IIIa-d).Hence both the types of isomeris