1282042-08-3Relevant academic research and scientific papers
6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors
Coffman, Karen,Brodney, Michael,Cook, James,Lanyon, Lorraine,Pandit, Jayvardhan,Sakya, Subas,Schachter, Joel,Tseng-Lovering, Elaine,Wessel, Matthew
, p. 1429 - 1433 (2011/04/23)
The synthesis and structure-activity relationships for a novel series of 6-amino-4-(pyrimidin-4-yl)pyridones derived from a high throughput screening hit are discussed. Optimization of lead matter afforded compounds with good potency, selectivity and central nervous system (CNS) exposure.
