128220-34-8

Basic information

• Product Name: methyl 6-methoxy-2-phenylquinoline-4-carboxylate
• Synonyms: methyl 6-methoxy-2-phenylquinoline-4-carboxylate
• CAS NO: 128220-34-8
• Molecular Weight: 293.322
• Mol File: 128220-34-8.mol

Chemical Properties

• CAS DataBase Reference: methyl 6-methoxy-2-phenylquinoline-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-methoxy-2-phenylquinoline-4-carboxylate(128220-34-8)
• EPA Substance Registry System: methyl 6-methoxy-2-phenylquinoline-4-carboxylate(128220-34-8)

Safety Data

• Hazardous Substances Data: 128220-34-8(Hazardous Substances Data)

Upstream product

• 105-64-6 diisopropyl peroxydicarbonate 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 292638-85-8 acrylic acid methyl ester 
• 74-88-4 methyl iodide 
• 32795-58-7 2-phenyl-6-methoxyquinoline-4-carboxylic acid 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 600-22-6 pyruvic acid methyl ester 

Relevant articles and documents

Triple zirconocene/br?nsted acid/CuO cooperative and relay catalysis system for tandem Mannich addition/C-C formative cyclization/oxidation

A new triple cooperative and relay catalysis system featuring the Mannich addition followed by C-C construction and oxydehydrogenation is described. The zirconocene dichloride and trimellitic acid synergic catalysis triggered the Mannich addition and C-C bond construction reactions, while CuO allowed relay catalysis for oxydehydrogenation. This novel strategy demonstrated superior activity for the synthesis of substituted quinolines from commercially available anilines, aldehydes and ketones. The corresponding substituted quinolines were synthesized with 32 examples in 90-96% yields under mild reaction conditions. A novel zirconocene-Br?nsted acid complex, generated in situ and acting as an active catalyst, was validated from the mechanistic studies.

Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors

A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A2 (hnps-PLA2) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA2 inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 μM. The structure-inhibition-activity relationships of the compounds were studied using molecular docking.

THE REACTION OF IMIDOYL RADICALS WITH MULTIPLE CARBON-CARBON BONDS

A general view on the reaction between imidoyl radicals and carbon-carbon double or triple bonds is given; the synthesis of substituted quinolines starting from imines and alkenes is described, pointing out the differences with respect to the analogous reaction performed with alkynes.