128237-30-9

Usage

Uses

Used in Organic Synthesis:
(R)-3-Hydroxyglutarate ethyl tert-butyl is used as a building block in organic synthesis for its versatile reactivity and ability to form various complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (R)-3-Hydroxyglutarate ethyl tert-butyl is used as a key intermediate in the development of new drugs, owing to its potential to be incorporated into diverse molecular structures with therapeutic properties.
Used in Biochemical Studies:
(R)-3-Hydroxyglutarate ethyl tert-butyl is utilized in biochemical research to investigate its interactions with biological systems and understand its role in metabolic pathways, potentially leading to insights into diseases and the development of targeted therapies.

Upstream product

• 95310-87-5 (3S)-5-ethoxy-3-hydroxy-5-oxopentanoic acid 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 615556-98-4 tert-butyl (3R)-3-(tert-butyldimethylsilyloxy)-6-dimethoxyphosphinyl-5-oxohexanate 
• 676256-39-6 tertiary butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-(E)-6-heptenoate 
• 355806-00-7 rosuvastatin tert-butyl ester 

Relevant academic research and scientific papers

Method for preparing of chiral intermediate and method for the preparing of HMG-CoA reductase inhibitor using chiral intermadiate

Chiral compounds and manufacturing method of the present invention refers to using the same manufacturing method relates to number of HMG-COa reduction inhibitors, more specifically an HMG-COa-reduction inhibitors number jaws statin compound in number of chiral intermediates that can be used a reaction steps, mild, and endangering a simple method and in high yield and purity can be under trillion number, purity statin compound is mirror number under trillion number on a commercial scale in can manufacturing method and [...] compounds using the same number of HMG-COa reduction inhibitors relates to manufacturing method. (by machine translation)

Ruthenium-catalyzed asymmetric hydrogenation of 3-oxoglutaric acid derivatives: A study of unconventional solvent and substituent effects

A series of 3-oxoglutaric acid derivatives have been hydrogenated in different solvents in the presence of [RuCl(benzene)(S)-SunPhos]Cl (SunPhos=(2,2,2′,2′-tetramethyl-[4,4′-bibenzo[d][1,3]dioxole] -5,5′-diyl)bis(diphenylphosphine)). Unlike simple β-keto acid derivatives, these advanced analogues can be readily hydrogenated in uncommon solvents such as THF, CH2Cl2, acetone, and dioxane with high enantioselectivities. Two possible catalytic cycles have been proposed to explain the different reactivities of these 1,3,5-tricarbonyl substrates in the tested solvents. The C-2 and C-4 substituents had notable but irregular influence on the reactivity and enantioselectivity of the reactions. More pronounced solvent effects were observed: the ee values increased from around 20 % in EtOH or THF to 90 % in acetone. Inversion of the product configuration was observed when the solvent was changed from EtOH to THF or acetone, and a mixed solvent system can lead to better enantioselectivity than a single solvent. Pronounced solvent effects: 3-Oxoglutaric acid derivatives have been hydrogenated in various solvents with high enantioselectivities (see scheme). Inversions of the product configuration were observed when the solvent was changed. Mixed solvent systems can give better enantioselectivities than a single solvent.

A Practical Synthesis of (R) and (S) 3-Hydroxyglutaric Acid Monoesters by Enzymatic Hydrolysis with a Bacterial Esterase

The hemihydrolysis of diethyl-3-hydroxyglutarate with an industrial enzyme, "Esterase 30 000", in a biphasic system allows an efficient enantioselective synthesis of (R) and (S) 3-hydroxyglutaric acid ethyl and t-butyl monoesters in large scale and with excellent yield.