128237-30-9

Basic information

• Product Name: (R)-3-HYDROXYGLUTARATE ETHYL TERT-BUTYL
• Synonyms: TERT-BUTYL ETHYL (R)-3-HYDRO-XYGLUTARATE;(R)-3-HYDROXYGLUTARATE ETHYL TERT-BUTYL;(3R)-3-Hydroxypentanedioic acid tert-butyl ethyl ester
• CAS NO: 128237-30-9
• Molecular Formula: C₁₁H₂₀O₅
• Molecular Weight: 232.27
• Product Categories: Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds
• Mol File: 128237-30-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 317℃
• Flash Point: 112℃
• Appearance: /
• Density: 1.080
• CAS DataBase Reference: (R)-3-HYDROXYGLUTARATE ETHYL TERT-BUTYL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-HYDROXYGLUTARATE ETHYL TERT-BUTYL(128237-30-9)
• EPA Substance Registry System: (R)-3-HYDROXYGLUTARATE ETHYL TERT-BUTYL(128237-30-9)

Safety Data

• Hazardous Substances Data: 128237-30-9(Hazardous Substances Data)

Usage

General Description

"(R)-3-Hydroxyglutarate ethyl tert-butyl" is a chemical compound with the molecular formula C10H18O5. It is an ester derivative of (R)-3-hydroxyglutarate, which is a key intermediate in the tricarboxylic acid cycle. (R)-3-HYDROXYGLUTARATE ETHYL TERT-BUTYL is commonly used as a building block in organic synthesis and pharmaceutical research. It is a colorless liquid with a characteristic odor, and it is considered to be stable under normal storage conditions. It has a wide range of potential applications in the fields of medicine, biochemistry, and chemical synthesis.

Upstream product

• 95310-87-5 (3S)-5-ethoxy-3-hydroxy-5-oxopentanoic acid 
• 75-65-0 tert-butyl alcohol 
• 115-11-7 isobutene 

Downstream Products

• 615556-98-4 tert-butyl (3R)-3-(tert-butyldimethylsilyloxy)-6-dimethoxyphosphinyl-5-oxohexanate 
• 676256-39-6 tertiary butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-(E)-6-heptenoate 
• 355806-00-7 rosuvastatin tert-butyl ester 

Relevant articles and documents

Method for preparing of chiral intermediate and method for the preparing of HMG-CoA reductase inhibitor using chiral intermadiate

Chiral compounds and manufacturing method of the present invention refers to using the same manufacturing method relates to number of HMG-COa reduction inhibitors, more specifically an HMG-COa-reduction inhibitors number jaws statin compound in number of chiral intermediates that can be used a reaction steps, mild, and endangering a simple method and in high yield and purity can be under trillion number, purity statin compound is mirror number under trillion number on a commercial scale in can manufacturing method and [...] compounds using the same number of HMG-COa reduction inhibitors relates to manufacturing method. (by machine translation)

A Practical Synthesis of (R) and (S) 3-Hydroxyglutaric Acid Monoesters by Enzymatic Hydrolysis with a Bacterial Esterase

The hemihydrolysis of diethyl-3-hydroxyglutarate with an industrial enzyme, "Esterase 30 000", in a biphasic system allows an efficient enantioselective synthesis of (R) and (S) 3-hydroxyglutaric acid ethyl and t-butyl monoesters in large scale and with excellent yield.