128242-44-4

Upstream product

• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 128242-38-6 2,3-diisopropoxy-4-phenyl-4-(trimethylsiloxy)-2-cyclobuten-1-one 
• 32264-87-2 2-cyclobuten-1-one 
• 114094-64-3 2,3-bis(1-methylethoxy)-4-hydroxy-4-phenylcyclobut-2-en-1-one 

Downstream Products

• 128242-74-0 3-(1-hexynyl)-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) 
• 128242-58-0 4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal 
• 138151-76-5 4-hydroxy-2-isopropoxy-4-methyl-3-phenyl-2-cyclobutenone ethylene acetal 
• 128242-57-9 4-tert-butyl-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal 
• 22315-46-4 bromo-phenyl-cyclobutenedione 
• 16547-35-6 2-methyl-3-phenyl-4-chloro-3-cyclobutenone 
• 106912-94-1 2-methyl-[1,1’-biphenyl]-3-ol 
• 138151-79-8 2-hydroxy-4-methyl-3-phenyl-3-cyclobutenone 
• 138151-77-6 3-methyl-4-phenyl-3-cyclobutene-1,2-dione 2-ethylene acetal 
• 138151-78-7 2-hydroxy-4-methyl-3-phenyl-3-cyclobutenone ethylene acetal 
• 128242-73-9 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) 
• 152931-88-9 3-phenyl-4-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione-1-ethylene acetal 

Relevant academic research and scientific papers

BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS

The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).

Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising

Regiospecific Preparation of Cyclobutenedione Monoacetals

Treatment of 2,3-diisopropoxy-4-hydroxy-4-organyl-2-cyclobuten-1-ones, prepared by addition of nucleophiles (H-, C-sp3, C-sp2, C-sp) to diisopropyl squarate, with Me3SiOCH2CH2OSiMe3 and catalytic trimethylsilyl triflate in