128242-99-9

Basic information

• Product Name: 4-Thiazolecarboxylicacid,2-methyl-5-(methylamino)-,ethylester(9CI)
• Synonyms: 4-Thiazolecarboxylicacid,2-methyl-5-(methylamino)-,ethylester(9CI);ethyl 2-methyl-5-(methylamino)thiazole-4-carboxylate
• CAS NO: 128242-99-9
• Molecular Formula: C₈H₁₂N₂O₂S
• Molecular Weight: 200.26
• Product Categories: AMINOACID
• Mol File: 128242-99-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Thiazolecarboxylicacid,2-methyl-5-(methylamino)-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylicacid,2-methyl-5-(methylamino)-,ethylester(9CI)(128242-99-9)
• EPA Substance Registry System: 4-Thiazolecarboxylicacid,2-methyl-5-(methylamino)-,ethylester(9CI)(128242-99-9)

Safety Data

• Hazardous Substances Data: 128242-99-9(Hazardous Substances Data)

Upstream product

• 1047675-70-6 5-bromo-2-methylthioazole-4-carboxylic acid ethyl ester 
• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 
• 74-88-4 methyl iodide 
• 31785-05-4 5-amino-2-methyl-1,3-thiazole-4-carboxylic acid ethyl ester 
• 128242-88-6 2-methyl-4-<(N-methylamino)carbonyl>-5-ethoxyoxazole 
• 128269-81-8 2-methyl-4-<(N-methylamino)thiocarbonyl>-5-ethoxyoxazole 
• 3357-62-8 2-methyl-4-(chlorocarbonyl)-5-ethoxyoxazole 
• 3357-55-9 ethyl 5-methoxy-2-methyl-1,3-oxazole-4-carboxylate 
• 3357-56-0 2-methyl-5-ethoxyoxazole-4-carboxylic acid 

Relevant articles and documents

Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

Focal adhesion kinase (FAK) is a tyrosine kinase with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival and is an attractive target for the development of cancer therapeutics. However, current FAK inhibitors display dual kinase inhibition and/or significant activity on several kinases. Although multitargeted activity is at times therapeutically advantageous, such behavior can also lead to toxicity and confound chemical-biology studies. We report a novel series of small molecules based on a tricyclic pyrimidothiazolodiazepinone core that displays both high potency and selectivity for FAK. Structure-activity relationship (SAR) studies explored modifications to the thiazole, diazepinone, and aniline "tail,"which identified lead compound BJG-03-025. BJG-03-025 displays potent biochemical FAK inhibition (IC50 = 20 nM), excellent kinome selectivity, activity in 3D-culture breast and gastric cancer models, and favorable pharmacokinetic properties in mice. BJG-03-025 is a valuable chemical probe for evaluation of FAK-dependent biology.

Rearrangement of 4-(Aminothiocarbonyl)oxazoles to 5-Aminothiazoles. Synthetic and MINDO/3 MO Studies

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