1282435-99-7Relevant academic research and scientific papers
From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies
Martin, Kevin S.,Soldi, Cristian,Candee, Kellan N.,Wettersten, Hiromi I.,Weiss, Robert H.,Shaw, Jared T.
, p. 260 - 264 (2013/03/29)
A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a "one-bead, one-compound" combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy.
