1282444-70-5Relevant academic research and scientific papers
A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO
Shen, Wei-Guo,Wu, Qing-Yan,Gong, Xing-Yu,Ao, Gui-Zhen,Liu, Feng
, p. 2983 - 2987 (2019)
A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of β-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.
A practical method for metal-free radical trifluoromethylation of styrenes with NaSO2CF3
Luo, Hai-Qing,Zhang, Zhi-Peng,Dong, Wen,Luo, Xu-Zhong
supporting information, p. 1307 - 1311 (2014/06/10)
A mild and practical protocol for the metal-free trifluoromethylation of styrenes using NaSO2CF3 (Langlois reagent) and TBHP was developed. The approach provides efficient access to α-trifluoromethylated ketones and alcohols in moderate to good yields. Georg Thieme Verlag Stuttgart New York.
