1282581-80-9Relevant academic research and scientific papers
Two 1,4-dihydro-pyridine derivatives with potential calcium-channel antagonist activity
Linden, Anthony,Safak, Cihat,Simsek, Rahime,Guenduez, Miyase G.
, p. o80-o84 (2011)
The title compounds, benzyl 4-(3-chloro-2-fluoro-phenyl)-2-methyl-5-oxo-4, 5,6,7-tetra-hydro-1H-cyclo-penta-[b]pyridine-3-carboxyl-ate, C 23H19ClFNO3, (I), and 3-pyridyl-methyl 4-[2-fluoro-3-(trifluoro-methyl)phenyl]-2,6,6
Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators
Guenduez,Safak,Kaygsz,Kosar,Simsek,Erol,Linden
experimental part, p. 167 - 175 (2012/09/08)
In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators. Georg Thieme Verlag KG Stuttgart · New York.
