128287-91-2Relevant academic research and scientific papers
Formal [1 + 2 + 3] Annulation: Domino Access to Carbazoles and Indolocarbazole Alkaloids
Men, Yang,Hu, Zhongyan,Dong, Jinhuan,Xu, Xianxiu,Tang, Bo
, p. 5348 - 5352 (2018/09/13)
A new formal [1 + 2 + 3] annulation of o-alkenyl arylisocyanides with α, β-unsaturated ketones under metal-, base-, and acid-free conditions is disclosed. This domino reaction provides a general protocol for the efficient and practical synthesis of a wide range of carbazole derivatives from readily available starting materials in a single operation. Furthermore, this methodology was used as the key step in a protecting-group-free synthesis of indolocarbazole alkaloids arcyriaflavin A and racemosin B.
New synthetic approach to arcyriaflavin-A and unsymmetrical analogs
Adeva, Marta,Buono, Frédéric,Caballero, Esther,Medarde, Manuel,Tomé, Fernando
, p. 832 - 834 (2007/10/03)
A new synthetic approach to the natural product arcyriaflavin-A and unsymmetrical analogs is described. The approach is based on successive Diels-Alder cycloaddition, Fischer indolization and formal nitrene insertion processes.
Synthesis of the Staurosporine Aglycon
Moody, Christopher J.,Rahimtoola, Kulsum F.,Porter, Barry,Ross, Barry C.
, p. 2105 - 2114 (2007/10/02)
A short synthesis of the staurosporine aglycon (6) is reported, the indolocarbazole skeleton being constructed by an intramolecular Diels-Alder reaction followed by a nitrene-mediated ring closure.The synthesis starts by acylation of ethyl indole-2-acetat
