128307-32-4Relevant academic research and scientific papers
Reaction of Nitriles under Acidic Conditions. Part VI. Synthesis of Condensed 4-Chloro- and 4-Aminopyrimidines from ortho-Aminonitriles
Shishoo, C. J.,Devani, M. B.,Bhadti, V. S,Jain, K. S.,Ananthan, S.
, p. 119 - 126 (2007/10/02)
Condensation of a nitrile with benzene, furan and thiophene ortho-aminonitriles in the presence of dry hydrogen chloride yields condensed 4-chloropyrimidines, condensed 4-aminopyrimidines or a mixture of the two condensed pyrimidines in varying proportions depending upon the nature of the nitrile and the substrate, ortho-aminonitrile.
