1283073-97-1Relevant academic research and scientific papers
Nanocrystalline magnesium oxide-stabilized palladium(0): An efficient and reusable catalyst for synthesis of N-(2-pyridyl)indoles
Reddy, Police Vishnuvardhan,Annapurna, Manne,Srinivas, Pottabathula,Likhar, Pravin R.,Lakshmi Kantam, Mannepalli
, p. 3399 - 3404 (2015)
A selective and efficient catalytic process has been developed for the oxidative coupling between N-aryl-2-aminopyridines and alkynes using a nanocrystalline magnesium oxide (NAP-MgO)-supported palladium nanoparticle [NAP-Mg-Pd(0)] catalyst and CuCl2 as an oxidant. The process involves the ortho C-H activation of N-aryl-2-aminopyridines to give N-pyridyl indoles in excellent yields and the true heterogeneity of the catalyst is verified by studying the recoverability and reusability for four cycles without significant loss of catalytic activity.
Synthesis of N-(2-pyridyl)indoles via Pd(II)-catalyzed oxidative coupling
Chen, Jinlei,Pang, Qingyu,Sun, Yanbo,Li, Xingwei
supporting information; experimental part, p. 3523 - 3526 (2011/06/24)
Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C-H activation of N-aryl-2-aminopyridines, and CuCl2 was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.
