1283073-98-2Relevant academic research and scientific papers
Ruthenium-Catalyzed Electrochemical Dehydrogenative Alkyne Annulation
Xu, Fan,Li, Yan-Jie,Huang, Chong,Xu, Hai-Chao
, p. 3820 - 3824 (2018/05/22)
A ruthenium-catalyzed electrochemical dehydrogenative annulation reaction of aniline derivatives and alkynes has been developed for the synthesis of indoles. Electric current is used to recycle the active ruthenium-based catalyst and promote H2 evolution. The electrolysis reaction is operationally convenient as it employs a simple undivided cell, proceeds efficiently in an aqueous solution, and is insensitive to air.
Nanocrystalline magnesium oxide-stabilized palladium(0): An efficient and reusable catalyst for synthesis of N-(2-pyridyl)indoles
Reddy, Police Vishnuvardhan,Annapurna, Manne,Srinivas, Pottabathula,Likhar, Pravin R.,Lakshmi Kantam, Mannepalli
, p. 3399 - 3404 (2015/05/20)
A selective and efficient catalytic process has been developed for the oxidative coupling between N-aryl-2-aminopyridines and alkynes using a nanocrystalline magnesium oxide (NAP-MgO)-supported palladium nanoparticle [NAP-Mg-Pd(0)] catalyst and CuCl2 as an oxidant. The process involves the ortho C-H activation of N-aryl-2-aminopyridines to give N-pyridyl indoles in excellent yields and the true heterogeneity of the catalyst is verified by studying the recoverability and reusability for four cycles without significant loss of catalytic activity.
Nickel-catalyzed alkyne annulation by anilines: Versatile indole synthesis by C-H/N-H functionalization
Song, Weifeng,Ackermann, Lutz
supporting information, p. 6638 - 6640 (2013/07/26)
Versatile nickel catalysts enabled the step-economical synthesis of decorated indoles through alkyne annulations with anilines bearing removable directing groups. The C-H/N-H activation strategy efficiently occurred in the absence of any metal oxidants and with excellent selectivities.
Synthesis of N-(2-pyridyl)indoles via Pd(II)-catalyzed oxidative coupling
Chen, Jinlei,Pang, Qingyu,Sun, Yanbo,Li, Xingwei
supporting information; experimental part, p. 3523 - 3526 (2011/06/24)
Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C-H activation of N-aryl-2-aminopyridines, and CuCl2 was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.
