1283074-01-0Relevant articles and documents
Synthesis of N-(2-pyridyl)indoles via Pd(II)-catalyzed oxidative coupling
Chen, Jinlei,Pang, Qingyu,Sun, Yanbo,Li, Xingwei
, p. 3523 - 3526 (2011)
Readily available Pd(II) chloride catalysts can catalyze selective and efficient oxidative coupling between N-aryl-2-aminopyridines and internal alkynes to yield N-(2-pyridyl)indoles. This process involves the ortho C-H activation of N-aryl-2-aminopyridines, and CuCl2 was used as an oxidant. Compared to our previously reported Rh(III)-catalyzed synthesis of this class of product, this method is advantageous with a wider scope of alkynes and cost-effective Pd(II) catalysts. Molecular oxygen can be used as a terminal oxidant.