13134-34-4

Basic information

• Product Name: Pyrazinamine, N-phenyl-
• CAS NO: 13134-34-4
• Molecular Formula: C10H9N3
• Molecular Weight: 171.202
• Mol File: 13134-34-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 311.5±22.0 °C(Predicted)
• Density: 1.206±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Pyrazinamine, N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinamine, N-phenyl-(13134-34-4)
• EPA Substance Registry System: Pyrazinamine, N-phenyl-(13134-34-4)

Safety Data

• Hazardous Substances Data: 13134-34-4(Hazardous Substances Data)

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 945-51-7 1,1'-sulfinylbisbenzene 
• 139-66-2 diphenyl sulfide 
• 108-86-1 bromobenzene 
• 14508-49-7 2-chloropyrazin 
• 62-53-3 aniline 
• 3149-28-8 2-methoxypyrazine 

Downstream Products

• 245-49-8 benzo[4,5]imidazo[1,2-a]pyrazine 
• 1402816-47-0 1-acetyl-1-tert-butyl-3-phenyl-3-pyrazin-2-yl-urea 
• 1283074-01-0 C₂₄H₁₇N₃ 

Relevant articles and documents

Palladium-Catalyzed Amination of Aryl Sulfides and Sulfoxides with Azaarylamines of Poor Nucleophilicity

The amination of aryl sulfides and sulfoxides with azaarylamines is investigated using a palladium-N-heterocyclic carbene (NHC) complex. Because azaarylamines are less nucleophilic than anilines, more reactive diaryl sulfides and sulfoxides are found to be suitable coupling partners that liberate better leaving arenethiolate or arenesulfenate anions, instead of aryl methyl sulfides as reported previously.

Synthesis method of aza-arylamine compound and aza-arylamine compound

The invention provides a synthesis method of an aza-arylamine compound as shown in a formula (I). The synthesis method comprises the following steps: an aza aromatic hydrocarbon compound as shown in aformula (II) reacts with an amine compound as shown in a formula (III) in presence of alkali and under a heating condition, so that u X substituent groups on an A ring of the compound as shown in theformula (II) are substituted by NRR in the compound as shown in the formula (III), and the compound as shown in the formula (I) is obtained, wherein A is an aza six-membered aromatic ring or five-membered aromatic ring, and is an independent single ring or is fused with a ring B; X refers to that the A ring has at least n X substituent groups, each X substituent group is independently selected from the group consisting of F, Cl, Br, I, CN, alkoxy of C and alkylthio of C, and n is a positive integer selected from 1-5; and the alkali is one or a mixture of more selected fromof BuOK, BuONa, BuONa, KHMDS, NaHMDS and LiHMDS. The synthesis method provided by the invention does not need the use of transition metal catalysts, is simple and convenient to operate, is economical and practical and is environmentally friendly. In addition, the invention also provides the aza-arylamine compound prepared by the method.

Ligand free copper-catalyzed N-arylation of heteroarylamines

An efficient protocol for ligand-free Cu-catalyzed N-arylation of heteroarylamines has been developed. With the use of 1% CuI, a wide range of aryl iodides and bromides coupled with heteroarylamines to afford the corresponding products in high yields. Further, this protocol is particularly suitable for reactions of the most hindered aryl iodides with 2-aminopyridines.